{"id":372950,"date":"2024-10-20T02:31:39","date_gmt":"2024-10-20T02:31:39","guid":{"rendered":"https:\/\/pdfstandards.shop\/product\/uncategorized\/bs-iso-192902021\/"},"modified":"2024-10-26T04:25:40","modified_gmt":"2024-10-26T04:25:40","slug":"bs-iso-192902021","status":"publish","type":"product","link":"https:\/\/pdfstandards.shop\/product\/publishers\/bsi\/bs-iso-192902021\/","title":{"rendered":"BS ISO 19290:2021"},"content":{"rendered":"

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS\/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).<\/p>\n

PDF Catalog<\/h4>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
PDF Pages<\/th>\nPDF Title<\/th>\n<\/tr>\n
2<\/td>\nundefined <\/td>\n<\/tr>\n
6<\/td>\nForeword <\/td>\n<\/tr>\n
7<\/td>\nIntroduction <\/td>\n<\/tr>\n
8<\/td>\n1 Scope
2 Normative references
3 Terms and definitions <\/td>\n<\/tr>\n
9<\/td>\n4 Principle
5 Apparatus
6 Reagents <\/td>\n<\/tr>\n
10<\/td>\n7 Preparation
7.1 Preparation of glassware
7.2 Preparation of solutions <\/td>\n<\/tr>\n
11<\/td>\n7.3 Preparation of standards
7.3.1 General
7.3.2 Preparation of internal standard solutions
7.3.3 Preparation of calibration standard solutions <\/td>\n<\/tr>\n
13<\/td>\n8 Sampling
9 Tobacco product preparation
10 Sample generation \u2014 Smoking of cigarettes
10.1 General
10.2 Linear smoking
10.3 Rotary smoking
11 Sample analysis
11.1 Preparation of sample
11.1.1 General
11.1.2 Extraction for linear smoking (44 mm pad)
11.1.3 Extraction for rotary smoking (92 mm pad)
11.1.4 Final sample preparation <\/td>\n<\/tr>\n
14<\/td>\n11.2 Reversed phase high performance liquid chromatography
11.2.1 General
11.2.2 HPLC set-up parameters (Example)
11.2.3 Mobile phase (Example)
11.2.4 Mobile phase: Gradient (Example)
11.2.5 MS\/MS Set-up parameters (Example) <\/td>\n<\/tr>\n
15<\/td>\n11.3 Calculation
11.3.1 Calibration curve <\/td>\n<\/tr>\n
16<\/td>\n11.3.2 Determination of the TSNAs concentrations
11.3.3 Sample quantification
11.3.4 Determination of mainstream smoke TSNA deliveries
12 Repeatability and reproducibility <\/td>\n<\/tr>\n
18<\/td>\n13 Test report <\/td>\n<\/tr>\n
19<\/td>\nAnnex A (informative) Example of typical chromatograms <\/td>\n<\/tr>\n
21<\/td>\nBibliography <\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Cigarettes. Determination of tobacco specific nitrosamines in mainstream cigarette smoke.Method using LC-MS\/MS<\/b><\/p>\n\n\n\n\n
Published By<\/td>\nPublication Date<\/td>\nNumber of Pages<\/td>\n<\/tr>\n
BSI<\/b><\/a><\/td>\n2021<\/td>\n22<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":372957,"template":"","meta":{"rank_math_lock_modified_date":false,"ep_exclude_from_search":false},"product_cat":[2641],"product_tag":[],"class_list":{"0":"post-372950","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bsi","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product\/372950","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media\/372957"}],"wp:attachment":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media?parent=372950"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_cat?post=372950"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_tag?post=372950"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}